NAD+ is one of the most important molecules in the body — and its levels decline with age. SEVEN offers clinician-guided NAD+ programs to support cellular energy, metabolic function, and long-term health optimization.
NAD+ serves as a critical cofactor in over 500 enzymatic reactions in the human body. It is central to mitochondrial function, DNA repair, and the activity of sirtuins — longevity-associated proteins that regulate cellular health. By age 50, NAD+ levels are roughly half of what they were at age 20.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It is essential for energy metabolism, cellular repair, and longevity-related biological processes.
NAD+ acts as a critical carrier of electrons in cellular metabolism — facilitating the conversion of nutrients into usable energy through the mitochondrial electron transport chain. Without adequate NAD+, cells cannot produce energy efficiently.
Beyond energy production, NAD+ is required for the activity of several important enzyme classes, including sirtuins (SIRT1-7) — proteins that regulate gene expression, stress responses, and longevity pathways — and PARPs, which are involved in DNA repair. Both of these processes are fundamental to healthy aging.
NAD+ levels decline progressively with age. This decline is associated with reduced mitochondrial function, increased cellular stress, metabolic dysfunction, and accelerated aging-related changes across multiple organ systems. Supporting NAD+ levels is a growing area of interest in longevity and metabolic medicine.
SEVEN's NAD+ programs are part of a broader metabolic health and longevity platform. They may be considered alongside GLP-1 programs, Sermorelin, or other protocols as part of an individualized clinical approach.
The following represents areas of active clinical interest in NAD+ research. Individual responses vary. All protocols are designed and supervised by licensed providers.
By supporting mitochondrial function, NAD+ supplementation may contribute to improved energy production at the cellular level — potentially translating to improved physical energy and reduced fatigue.
NAD+ is required for the activity of PARP enzymes involved in DNA damage repair. Supporting these pathways is a key area of interest in longevity medicine and cellular health research.
NAD+ supports neuronal health through its role in cellular energy and neuroprotective pathways. Preliminary research suggests potential cognitive benefits, though evidence is still developing.
NAD+ plays a role in metabolic signaling pathways including insulin sensitivity and lipid metabolism. These connections make it relevant in the context of broader metabolic health optimization.
Activation of sirtuin proteins — which require NAD+ as a cofactor — is associated with longevity-related biological processes including gene expression regulation and stress resistance.
Mitochondrial efficiency is central to physical endurance and recovery. Supporting NAD+ levels may contribute to improved exercise performance and recovery in some individuals.
Individual results vary and are not guaranteed. NAD+ therapy is not FDA-approved as a drug treatment. All protocols represent wellness and longevity medicine applications reviewed by licensed clinicians.
Multiple delivery methods exist for NAD+ supplementation. Your licensed provider determines the most appropriate approach based on your health profile and goals.
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are NAD+ precursors available in oral form. They are converted to NAD+ through cellular biosynthesis pathways and represent the most accessible form of NAD+ supplementation.
Subcutaneous NAD+ administration allows for more direct delivery than oral precursors. This approach is coordinated through SEVEN's clinical infrastructure and requires provider prescription and oversight.
Your licensed provider designs a protocol based on your health history, metabolic profile, and optimization goals. Frequency, dosing, and delivery method are individualized.
The bioavailability of oral NAD+ precursors has been an active area of research. Studies on NMN and NR have demonstrated measurable increases in circulating NAD+ levels following oral supplementation, though the degree of increase varies by individual and formulation.
Injectable forms of NAD+ supplementation provide more direct elevation of systemic NAD+ levels. The clinical decision between oral precursors and injectable administration depends on your goals, health status, and provider recommendation.
SEVEN's NAD+ programs may be considered alongside other metabolic health protocols including GLP-1 microdosing and Sermorelin when clinically appropriate.
Eligibility and protocol appropriateness are determined by a licensed clinician following individual health intake review.
Adults interested in proactive cellular health support and longevity medicine may be candidates for NAD+ programs as part of an integrated metabolic health approach.
Individuals addressing metabolic dysfunction, energy decline, or age-related metabolic changes may benefit from NAD+ as part of a broader protocol.
Adults seeking to support physical performance, endurance, and recovery through optimized cellular energy pathways.
Individuals interested in supporting cognitive function and neurological health through NAD+-dependent cellular pathways.